Evaluation of Kidney Functioning in Children with Renal Complications During COVID-19 Pandemic: A Retrospective Observational Cohort Clinical Study

Background . An increase in a quantity of children with acute renal insufficiency associated infectious diseases, including COVID-19 is growing problem nephrology. Such often expressed pyelonephritis. Due to lack specific signs or obvious clinical symptoms and their correct interpretation, against the background first identified period steady worsening kidney functioning. accurate non-invasive diagnostic test yet be fully developed, therefore, determination mechanisms complications considered challenging can contribute formation irreversible injury. Objective — determine evaluate characteristics status pyelonephritis COVID-19. Methods. A retrospective observational cohort study 65 was carried out. The also included control group 20 healthy children, who were observed during routine health checkup. patients at Nephrology Unit, Samarkand Regional Pediatric Multidisciplinary Medical Center, Uzbekistan. Laboratory examination out on basis Clinical Diagnostic Laboratory, Uzbekistan, Innova Clinic, conducted from January 2021 December 2022 involved participants history before treatment. Thus, two cohorts formed: 1 comprised 30 without COVID-19; 2 consisted 35 In order status, glomeruli, proximal distal tubules investigation “urinary syndrome” indicators leukocyturia neutrophil origin, microhematuria, proteinuria, bacteriuria. obtained laboratory data analyzed using variance given SI System International Units. calculations StatPlus 7 (AnalystSoft Inc., USA). Results. Renal function decreased an due reduced functionality concentration tubule, which more significantly affected 2. Inflammatory changes tissue toxic effects coronavirus infection underlie abnormalities detected. reckoned date admission ranges 3 weeks months. manifested irrespective polymorphism, impairment its tubular structures (reabsorption, acidogenesis ammoniogenesis, osmotic concentration) glomerular filtration. statistically significant reduction (p = 0.001) recorded COVID-associated Conclusion. Children respiratory require monitoring functions for early diagnosis Long-term isolated urinary syndrome needed detect underlying disease.